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The term ama ordinarly means unripe, uncooked, immature, and undigested. In the context of medicine, however, this term refers to events that follow and factors which arise, as a consequence of the impaired functioning of Kayagni. Due to the hypofunctioning of the agni, the first dhatu viz. the rasa (chyle) is not properly formed. Instead the annarasa undergoes fermentation and or putrefaction being retained in the amashaya. It is this state of rasa which is spoken of as ama.
Impairment of agni causes ama. But the impairment of agni can be caused due to:
Ayurveda calls it Ama Visha meaning poison. It can produce a similar effect like poison, if it is acute one may have gastroenteritis or death. If chronic, may produce different types of diseases mixing with vata, pitta or kapha. In reality this is one of the reasons for Auto immune disorders if the modern world. For eg. Rheumatoid arthritis. SLE, etc.